Copy number variation (CNV) is a structural variation at the submicroscopic level of the genome, which can affect gene-related phenotypes by changing genes dosage and transcript structure. Hematopoietic prostaglandin D synthase (HPGDS) is a member whose functions are closely related to weight gain and inflammatory diseases of the glutathione S-transferase (GSTs) family. In this study, the growth characteristics (body weight, withers height, body length, and chest girth) of 336 Ashidan yaks were monitored at four stages (6 months, 12 months, 18 months, and 30 months). In addition, CNV of the HPGDS gene was detected, discovered relationships of CNV with growth traits, and explored the level of gene expression. Based on the statistical analysis by IBM SPSS software, significant correlations were observed between HPGDS-CNV and body weight in 12-month-old yak (P < 0.01), 18-month-old yak (P < 0.001) and 30-month-old yak (P < 0.001) and body length in 18-month-old yak (P < 0.05) and 30-month-old yak (P < 0.05), respectively. Additionally, the individuals with gain copy number type performed better in body weight and body length than those with normal or loss copy number type. To our best of knowledge, this is the first time to make efforts to probe into the role of HPGDS-CNV and its interaction with livestock growth traits. Our results suggested that the CNV of the HPGDS gene may be an active candidate gene for the marker-assisted selection (MAS) of yaks.

拷贝数变异（CNV）是基因组亚微观水平的结构变异，可通过改变基因剂量和转录本结构来影响与基因相关的表型。造血前列腺素D合酶（HPGDS）是其功能与体重增加和谷胱甘肽S-转移酶（GSTs）家族的炎性疾病密切相关的成员。在这项研究中，在四个阶段（6个月，12个月，18个月和30个月）监测了336头Ashidan牛的生长特征（体重，肩高，身长和胸围）。另外，HPGDS的CNV检测基因，发现CNV与生长特性的关系，并探索基因表达水平。根据IBM SPSS软件的统计分析，在12个月大的ak牛（P <  0.01），18个月大的y牛（P <  0.001）和30个月大的-牛中，HPGDS -CNV与体重之间存在显着相关性。旧牦牛（P <0.001），并在18个月大的牦牛体长度（P <  0.05）和30个月大的牦牛（P <  0.05）分别。另外，具有复制号类型的个体的体重和体长比具有正常或丢失号类型的个体表现更好。据我们所知，这是第一次尝试探讨HPGDS -CNV及其与牲畜生长特性的相互作用。我们的结果表明，HPGDS基因的CNV可能是an牛标记辅助选择（MAS）的活跃候选基因。