Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskeletal comorbidities, the etiology of sarcopenia, and especially the contribution of cardiovascular aging is unclear. Aging-related vascular calcification is prevalent in older adults and is a known risk factor for cardiovascular disease and death. The effect vascular calcification has on function during aging is not well understood. Emerging findings suggest vascular calcification can impact skeletal muscle perfusion, negatively affecting nutrient and oxygen delivery to skeletal muscle, ultimately accelerating muscle loss and functional decline. The present review summarizes existing evidence on the biological mechanisms linking vascular calcification with sarcopenia during aging.

心血管和肌肉骨骼系统等生物结构与衰老相关的变化导致心血管疾病和虚弱等合并症的发展，并最终导致过早死亡。虽然，体弱的老年人经常表现出心血管和肌肉骨骼合并症，但肌肉减少症的病因，尤其是心血管衰老的贡献尚不清楚。与衰老相关的血管钙化在老年人中普遍存在，并且是心血管疾病和死亡的已知危险因素。血管钙化对衰老过程中功能的影响尚不清楚。新发现表明血管钙化会影响骨骼肌灌注，对骨骼肌的营养和氧气输送产生负面影响，最终加速肌肉流失和功能衰退。本综述总结了衰老过程中将血管钙化与肌肉减少症联系起来的生物学机制的现有证据。