With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of a systemic review. This review was carried out based on the existing PRISMA (Preferred Report for Systematic Review and Meta analyses) consensus statement. The data for this review was collected from four databases: Pubmed/Medline, NIH Litcovid, Embase, and Cochrane library and Preprint servers up till 30 June 2020. Search strategy comprised of a range of keywords from relevant medical subject headings which includes “SARS-COV-2,” “COVID-19,” and “meningoencephalitis.” All peer reviewed, case–control, case report, pre print articles satisfying our inclusion criteria were involved in the study. Quantitative data was expressed in mean ± SD, while the qualitative date in percentages. Paired t test was used for analysing the data based on differences between mean and respective values with a p < 0.05 considered to be statistically significant. A total of 61 cases were included from 25 studies after screening from databases and preprint servers, out of which 54 of them had completed investigation profile and were included in the final analysis. Clinical, laboratory findings, neuroimaging abnormalities, and EEG findings were analyzed in detail. This present review summarizes the available evidences related to the occurrence of meningoencephalitis in COVID-19.

近年来，随着 COVID-19 病例数量的不断增加。世界范围内已有大量患者出现肺部额外症状的报告。在这里，我们大胆地以系统评价的形式总结 SARS-CoV-2 相关脑膜脑炎患者的临床概况、调查和放射学结果。本次审查是根据现有的 PRISMA（系统审查和荟萃分析首选报告）共识声明进行的。本综述的数据收集自四个数据库：Pubmed/Medline、NIH Litcovid、Embase、Cochrane 图书馆和预印本服务器，截至 2020 年 6 月 30 日。搜索策略由相关医学主题标题中的一系列关键词组成，其中包括“SARS- COV-2”、“COVID-19”和“脑膜脑炎”。所有符合我们纳入标准的同行评审、病例对照、病例报告、预印文章都参与了这项研究。定量数据以平均值±标准差表示，而定性数据以百分比表示。配对t检验用于根据平均值和相应值之间的差异分析数据， p < 0.05 被认为具有统计显着性。从数据库和预印本服务器筛选后，共纳入 25 项研究的 61 例，其中 54 例已完成调查概况并纳入最终分析。详细分析了临床、实验室检查结果、神经影像学异常和脑电图检查结果。本综述总结了与 COVID-19 脑膜脑炎发生相关的现有证据。