Abstract At present, high-sensitivity, high-penetration-depth, and accurate tissue resolution clinical imaging effect are required, while computer transverse scanning, microwave imaging, and fluorescence imaging (FL) cannot meet the requirements of clinical imaging, but the magnetic resonance imaging (MRI) can meet the requirements of clinical dissecting details. The effect of MRI imaging is closely related to the contrast agent (CA). As an important type of CA, Fe3O4 and its analogues have been widely concerned because of their low toxicity and relatively low price. In this review, we summarize the development and improvement of CAs based on Fe3O4 and its analogues from T 2 imaging mode and development limitation in the initial single modulus imaging mode, to T 1 imaging mode overcoming the limitations of T 2 imaging and the limitations of its own in application, to the later development of dual modulus imaging form, and to the current multi-modulus imaging form. Simultaneously, we demonstrate the research progress, preparation methods, and future trends based on Fe3O4 and its analogues CAs for MRI, the current application status is preliminarily summarized, and the future development trend is prospected.

中文翻译：

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磁性Fe3O4纳米材料在磁共振成像中的研究进展

摘要 目前临床成像要求高灵敏度、高穿透深度、准确的组织分辨率，而计算机横向扫描、微波成像和荧光成像（FL）不能满足临床成像的要求，而磁共振成像（MRI）可以满足临床解剖细节的要求。MRI成像的效果与造影剂（CA）密切相关。Fe3O4及其类似物作为一种重要的CA类型，因其毒性低、价格相对低廉而受到广泛关注。在这篇综述中，我们从 T 2 成像模式和初始单模成像模式的发展限制总结了基于 Fe3O4 及其类似物的 CAs 的发展和改进，