Autophagy, a bulk degradation system conserved among most eukaryotes, is also involved in responses to viral infection in plant. In our previous study, a new host factor P3IP was identified to interact with RSV (rice stripe virus) p3 and mediate its autophagic degradation to limit the viral infection. Here, we further discovered that P3IP of Nicotiana benthamiana (NbP3IP) participated in regulation of autophagy. Overexpression of NbP3IP induced autophagy and down-regulation of NbP3IP reduced autophagy. Combined the functions of autophagy-mediated plant defense against plant virus and regulation autophagy, we indicate that P3IP participates in the regulation of autophagy.

中文翻译：

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植物蛋白P3IP参与本塞姆氏烟草自噬的调控


自噬是大多数真核生物中保守的大量降解系统，也参与植物对病毒感染的反应。在我们之前的研究中，发现了一种新的宿主因子 P3IP 与 RSV（水稻条纹病毒）p3 相互作用并介导其自噬降解以限制病毒感染。在这里，我们进一步发现本氏烟草的P3IP（NbP3IP）参与了自噬的调节。 NbP3IP 的过表达诱导自噬，NbP3IP 的下调会降低自噬。结合自噬介导的植物防御植物病毒和调节自噬的功能，我们表明P3IP参与了自噬的调节。