Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups: 1) exercise and isoflavone (Ex + Iso, n=27) or 2) isoflavone interventions (Iso; n=16). Participants of the Ex + Iso intervention group completed an 8-week aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or non-producers) were determined from urine equol concentrations after a soy challenge. In the Ex + Iso intervention group, carotid arterial compliance increased in the equol producers (0.084±0.030→0.117±0.035 mm²/mmHg) but not in the non-producers (0.089±0.028→0.097±0.026 mm²/mmHg) after the intervention (interaction effect; p<0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (p<0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.

中文翻译：

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雌二醇的产生状态影响运动训练引起的绝经后妇女动脉顺应性的改善

绝经后中央动脉顺应性急剧下降。定期摄入大豆异黄酮和有氧运动可增加动脉顺应性。雌马酚是肠道微生物组中异黄酮黄豆苷元的代谢产物。我们确定了雌马酚的产生状态是否影响有氧运动引起的颈动脉顺应性改善。43名绝经后妇女分为两个干预组：1）运动和异黄酮（Ex + Iso，n = 27）或2）异黄酮干预（Iso； n = 16）。Ex + Iso干预组的参与者完成了为期8周的有氧运动训练，并且所有参与者在干预期间均接受口服异黄酮补充剂的管理。根据大豆激发后尿中雌马酚的浓度确定雌马酚的生产状态（雌马酚生产者或非生产者）。²（mmHg），但非生产者（0.089±0.028→0.097±0.026 mm ² / mmHg）没有干预（相互作用效应； p <0.05）。雌马酚生产者的颈动脉顺应性增加幅度显着大于非雌马酚生产者（p <0.05）。在异黄酮干预组中，无论雌马酚状态如何，干预后任何参数均无变化。这些结果表明，雌马产生状态对于有氧运动训练引起的绝经后妇女中央动脉顺应性的改善是必不可少的。