Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti‐oxidative and anti‐inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL‐1β, IL‐6, IL‐8, IL‐17, IL‐22, TNF‐α and COX‐2) and regulate various signaling pathway (e.g., the NF‐κB, JAK–STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis. In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.

中文翻译：

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木犀草素作为皮肤老化和炎症的调节剂

木犀草素属于类黄酮，可以在花卉、草药、蔬菜和香料中找到。它在保护植物方面发挥着重要作用，例如通过部分吸收 UVA 和 UVB 辐射来抵御紫外线辐射。因此，木犀草素还可以作为第一道防线来减少皮肤中的不利光生物学效应。此外，木犀草素在角质形成细胞和成纤维细胞以及几种免疫细胞（例如，巨噬细胞、肥大细胞、中性粒细胞、树突状细胞和 T 细胞）上的抗氧化和抗炎活性被描述。木犀草素可以抑制促炎介质（如 IL-1β、IL-6、IL-8、IL-17、IL-22、TNF-α 和 COX-2）并调节各种信号通路（如 NF-κB、JAK –STAT 以及 TLR 信号通路）。通过这种方式，木犀草素调节皮肤的许多炎症过程。本综述总结了木犀草素在皮肤老化和皮肤癌、伤口愈合以及炎症性皮肤病（包括银屑病、接触性皮炎和特应性皮炎）领域的体外和体内研究。总之，木犀草素可能是开发针对炎症性皮肤病的局部制剂和全身药物的有前途的分子。