Surface enhanced Raman spectroscopy (SERS) has been proposed as a promising technique in biological and chemical sample detection. Herein, with nanographene oxide (nGO) as substrate, we firstly prepared facile platforms (PAMAM_G1-nGO-PEG and PAMAM_G3-nGO-PEG) through the functionalization of nGO with biocompatible poly(ethylene glycol) (PEG) and hyperbranched polyamidamine (PAMAM) dendrimer. nGO/gold nanoparticle nanocomposites (Au@PAMAM_G1-nGO-PEG and Au@PAMAM_G3-nGO-PEG) were aptly fabricated through in situ covering of gold nanoparticles on PEG/PAMAM-functionalized nGO. A series of techniques were employed to confirm the covalent modification of nGO with different functional polymers and the uniformity of gold nanoparticles scattered over the nGO sheets in the as-prepared nanocomposites. Evidently, taking advantages of inherent electrochemical property of gold nanoparticles and their good dispersity on polymers and functionalized nGO, Au@PAMAM_G1-nGO-PEG and Au@PAMAM_G3-nGO-PEG both displayed sensitive and efficient SERS detection towards p-phenylenediamine, flavin adenine dinucletide and crystal violet (CV) molecules. It is foreseen that these nanocomposites can meet diverse SERS sensing applications with good dispersity, especially for environmental and clinical samples.

已经提出表面增强拉曼光谱（SERS）作为生物和化学样品检测中的有前途的技术。在此，我们以纳米氧化石墨烯（nGO）为底物，首先通过将nGO与生物相容性聚乙二醇（PEG）和超支化聚酰胺胺（PAMAM _G1 -nGO-PEG和PAMAM _G3 -nGO-PEG）进行功能化制备了简便的平台。PAMAM）树状聚合物。通过原位制备nGO /金纳米颗粒纳米复合材料（Au @ PAMAM _G1 -nGO-PEG和Au @ PAMAM _G3 -nGO-PEG）在PEG / PAMAM功能化的nGO上覆盖金纳米颗粒。采用了一系列技术来确认nGO与不同功能性聚合物的共价修饰以及金纳米颗粒在制备的纳米复合材料中散布在nGO板上的均匀性。显然，利用金纳米颗粒固有的电化学性质以及它们在聚合物和官能化nGO上的良好分散性，Au @ PAMAM _G1 -nGO-PEG和Au @ PAMAM _G3 -nGO-PEG均显示出对p的灵敏且有效的SERS检测。-苯二胺，黄素腺嘌呤二核苷酸和结晶紫（CV）分子。可以预见，这些纳米复合材料可以满足各种具有良好分散性的SERS传感应用，尤其是对于环境和临床样品。