Interesterified fat (IF) currently substitutes the hydrogenated vegetable fat (HVF) in processed foods. However, the IF consumption impact on the central nervous system (CNS) has been poorly studied. The current study investigated connections between IF chronic consumption and locomotor impairments in early life period and adulthood of rats and access brain molecular targets related to behavior changes in adulthood offspring. During pregnancy and lactation, female rats received soybean oil (SO) or IF and their male pups received the same maternal supplementation from weaning until adulthood. Pups' motor ability and locomotor activity in adulthood were evaluated. In the adult offspring striatum, dopaminergic targets, glial cell line-derived neurotrophic factor (GDFN) and lipid profile were quantified. Pups from IF supplementation group presented impaired learning concerning complex motor skill and sensorimotor behavior. The same animals showed decreased locomotion in adulthood. Moreover, IF group showed decreased immunoreactivity of all dopaminergic targets evaluated and GDNF, along with important changes in FA composition in striatum. This study shows that the brain modifications induce by IF consumption resulted in impaired motor control in pups and decreased locomotion in adult animals. Other studies about health damages induced by IF consumption may have a contribution from our current outcomes.

中文翻译：

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自妊娠以来的酯化脂肪消耗降低纹状体多巴胺能目标水平和 gdnf 损害成年后代的运动

目前，酯化脂肪 (IF) 可替代加工食品中的氢化植物脂肪 (HVF)。然而，IF 消耗对中枢神经系统 (CNS) 的影响研究甚少。目前的研究调查了 IF 慢性消耗与大鼠生命早期和成年期运动障碍之间的联系，并获得了与成年后代行为变化相关的脑分子靶标。在怀孕和哺乳期间，雌性大鼠接受大豆油 (SO) 或 IF，它们的雄性幼崽从断奶到成年接受相同的母体补充。评估幼犬成年后的运动能力和运动能力。在成年后代纹状体中，对多巴胺能靶标、神经胶质细胞系衍生的神经营养因子 (GDFN) 和脂质谱进行了量化。来自 IF 补充组的幼崽表现出关于复杂运动技能和感觉运动行为的学习障碍。相同的动物在成年后表现出减少的运动。此外，IF 组显示评估的所有多巴胺能靶标和 GDNF 的免疫反应性降低，以及纹状体中 FA 组成的重要变化。这项研究表明，由 IF 消耗引起的大脑改变导致幼崽的运动控制受损和成年动物的运动能力下降。其他关于 IF 消费引起的健康损害的研究可能对我们目前的结果有所贡献。随着纹状体中 FA 组成的重要变化。这项研究表明，由 IF 消耗引起的大脑改变导致幼崽的运动控制受损和成年动物的运动能力下降。其他关于 IF 消费引起的健康损害的研究可能对我们目前的结果有所贡献。随着纹状体中 FA 组成的重要变化。这项研究表明，由 IF 消耗引起的大脑改变导致幼崽的运动控制受损和成年动物的运动能力下降。关于 IF 消费引起的健康损害的其他研究可能对我们目前的结果有所贡献。