Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father - of a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified in the proband. Peripheral blood mononuclear cells were obtained from all three individuals and reprogrammed using Sendai virus particles carrying the Yamanaka transgenes. These 3 iPSC lines (iPSC-SZ-HU-MO 1, iPSC-SZ-HU-FA 1, and iPSC-SZ-HU-PROB 1) represent a resource for examining the functional significance of the identified de novo mutations in the molecular pathophysiology of schizophrenia.

在这里，我们描述了参与外显子组测序研究的精神分裂症病例-父母三人组的每个成员（男性先证者，母亲，父亲）诱导多能干细胞系的产生，并在先证者中鉴定了3个从头突变。从所有三个人获得外周血单核细胞，并使用携带山中转基因的仙台病毒颗粒对其进行重编程。这3条iPSC品系（iPSC-SZ-HU-MO 1，iPSC-SZ-HU-FA 1和iPSC-SZ-HU-PROB 1）代表了一种资源，可用于检查分子中从头突变的功能重要性精神分裂症的病理生理学。