Purpose

Resolvin is a checkpoint controller in inflammation. Matrix metalloproteinase-9 (MMP-9) is an airway remodeling regulator. We evaluated the levels of resolvin and MMP-9 protein in the serum and exhaled breath condensate (EBC) before and after continuous positive airway pressure (CPAP) treatment.

Method

We enrolled 20 non-OSA snorers and 40 patients with moderate to severe OSA scheduled for CPAP treatment. ELISA was used to assess resolvin and MMP-9 levels in the serum and EBC. All patients underwent sleep assessment at baseline and 3 months after CPAP.

Results

There was no between-group difference; moreover, there were no differences in the pre- and post-treatment serum levels of resolvin and MMP-9 in patients with OSA. Compared with non-OSA snorers, patients with OSA had lower resolvin and higher MMP-9 levels in the EBC. After CPAP treatment, the EBC levels of resolvin and MMP-9 in patients with OSA returned to normal.

Conclusions

Successful OSA treatment by CPAP can normalize EBC levels of resolvin and MMP-9.

中文翻译：

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持续气道正压通气对阻塞性睡眠呼吸暂停患者resolvin和matrix metalloproteinase-9的影响

目的

Resolvin 是炎症的检查点控制器。基质金属蛋白酶 9 (MMP-9) 是一种气道重塑调节剂。我们评估了持续气道正压通气 (CPAP) 治疗前后血清和呼出气冷凝物 (EBC) 中的 resolvin 和 MMP-9 蛋白水平。

方法

我们招募了 20 名非 OSA 打鼾者和 40 名计划接受 CPAP 治疗的中度至重度 OSA 患者。ELISA 用于评估血清和 EBC 中的溶解蛋白和 MMP-9 水平。所有患者在基线和 CPAP 后 3 个月均接受睡眠评估。

结果

没有组间差异；此外，OSA患者治疗前后血清resolvin和MMP-9水平没有差异。与非 OSA 打鼾者相比，OSA 患者的 EBC 中的 Resolvin 较低，MMP-9 水平较高。CPAP治疗后，OSA患者的resolvin和MMP-9的EBC水平恢复正常。

结论

通过 CPAP 成功治疗 OSA 可以使 Resolvin 和 MMP-9 的 EBC 水平正常化。