The purpose of this article is to review the many facets of central nervous system tuberculosis (CNS-TB). The entities described are tuberculous meningitis (TBM) and its complications, spinal cord disorders, tuberculomas and co-infection with the human immune-deficiency virus (HIV). The latter has become a common problem worldwide becoming a more fulminant disease. The accuracy of the conventional and the modern molecular techniques for the diagnosis of TBM have a high specificity but a low to moderate sensitivity. Computerised tomographic scans and magnetic resonance imaging have many characteristic features which have vastly improved the diagnostic accuracy of CNS-TB. The recommended therapeutic regimens are an extrapolation of the regimen used for pulmonary TB, hence the optimal composition, dosage and duration of the therapy are not yet established. Multidrug resistant TB is emerging as a global threat and the delay in recognition of drug resistance combined with the lack of data on appropriate drug regimen adds to its high mortality.

中文翻译：

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中枢神经系统结核

本文的目的是回顾中枢神经系统结核病 (CNS-TB) 的许多方面。所描述的实体是结核性脑膜炎 (TBM) 及其并发症、脊髓疾病、结核瘤和人类免疫缺陷病毒 (HIV) 的合并感染。后者已成为世界范围内的普遍问题，成为一种更严重的疾病。常规和现代分子技术诊断TBM的准确性具有较高的特异性，但敏感性较低。计算机断层扫描和磁共振成像具有许多特征，极大地提高了 CNS-TB 的诊断准确性。推荐的治疗方案是对用于肺结核的方案的外推，因此是最佳组合物，治疗的剂量和持续时间尚未确定。耐多药结核病正在成为一种全球性威胁，耐药性识别的延迟加上缺乏适当药物治疗的数据增加了其高死亡率。