Abstract In the current study, by applying the mixed-ligand approach, two new Cu(II)-based coordination polymers with the chemical formulae of {[Cu(Py 2 TTz)(BDC)](DMF)} n ( 1 ) and {[Cu 2 (Py 2 TTz) 2 (BDC) 2 ]· 2(DMF)·0.5(H 2 O)} n ( 2 ) are successfully prepared from a rigid N-donor linker 2,5-bis(4-pyridyl)thiazolo[5,4-d]thiazole (Py 2 TTz) and linear carboxylate ligands of 1,4-benzenedicarboxylic acid (H 2 BDC) under different reaction conditions. Then, the therapeutic activity of the compounds on the children sepsis is evaluated. Firstly, the percentage of lymphocyte apoptosis after treating with the compounds is measured with the V-FITC/PI staining assay. Next, the serum procalcitonin (PCT) content during sepsis after treating with the compounds is determined with the ELISA detection kit.

中文翻译：

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两种基于铜 (II) 的配位聚合物：降低血清降钙素原产生的活性和对儿童败血症的保护作用

摘要 在目前的研究中，通过应用混合配体方法，两种新的 Cu (II) 基配位聚合物的化学式为 {[Cu (Py 2 TTz) (BDC)] (DMF)} n (1) 和{[Cu 2 (Py 2 TTz) 2 (BDC) 2] · 2 (DMF) · 0.5 (H 2 O)} n (2) 从刚性 N 供体接头 2,5-bis (4-吡啶基)噻唑并[5,4-d]噻唑(Py 2 TTz)和1,4-苯二甲酸(H 2 BDC)在不同反应条件下的线性羧酸盐配体。然后，评价化合物对儿童败血症的治疗活性。首先，用V-FITC/PI染色测定法测量用化合物处理后的淋巴细胞凋亡百分比。接下来，用ELISA检测试剂盒测定用化合物治疗后败血症期间的血清降钙素原(PCT)含量。