Abstract

The effect of HDACs 4 and 5 on the level of atrophy, calpain-1 and titin content, and TTN gene expression in rat soleus after 7-day gravitational unloading (hindlimb suspension model) was studied. The development of atrophic changes induced by gravitational unloading in rat soleus was accompanied by an increase in the calpain-1 content, an increase in titin proteolysis, and a decrease in the mRNA content of the protein. Inhibition of HDACs 4 and 5 did not eliminate the development of unloading-induced atrophy but significantly prevented proteolysis of titin and the decrease in the TTN gene expression.

中文翻译：

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七天后肢卸载后，抑制组蛋白脱乙酰基酶4和5减少了Titin蛋白水解并防止TTN基因表达在萎缩大鼠比目鱼肌中减少。

摘要

研究了HDAC 4和5对重力作用7天后大鼠比目鱼肌萎缩程度，钙蛋白酶-1和肌酐含量以及TTN基因表达的影响（后肢悬吊模型）。由大鼠比目鱼的重力卸载引起的萎缩性变化的发展伴随着calpain-1含量的增加，titin蛋白水解的增加以及蛋白的mRNA含量的下降。HDAC 4和5的抑制并不能消除由卸载引起的萎缩的发展，但可以显着阻止titin的蛋白水解和TTN基因表达的下降。