Abstract

The study was carried out on samples of invasive breast carcinoma of no special type from 36 patients aged 48.0 to 62.8 years. The effect of HLDF on nonspecific invasive breast carcinoma was a decrease in the relative content of low-differentiated cells and an increase in the relative content of highly differentiated cells. HLDF did not have a cytotoxic effect leading to the death of low-differentiated cells but promoted promotes the acquisition of a higher degree of differentiation by them. A more pronounced effect of HLDF was observed in more aggressive metastasizing forms of neoplasia, which allows us to consider this differentiation factor as a candidate for use in the differentiation therapy of malignant neoplasms.

中文翻译：

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HLDF分化因子对体外非特异性侵袭性乳腺癌的影响

摘要

该研究是针对36名年龄在48.0至62.8岁的浸润性乳腺癌样本进行的。HLDF对非特异性浸润性乳腺癌的作用是低分化细胞相对含量的减少和高分化细胞相对含量的增加。HLDF没有导致低分化细胞死亡的细胞毒性作用，但被促进促进了高分化细胞的获得。在更具侵袭性的肿瘤形成转移形式中观察到了HLDF的更为明显的作用，这使我们可以将此分化因子视为恶性肿瘤分化治疗中的候选药物。