Abstract

In recent years, silicon dioxide nanoparticles have been widely used in medicine and the pharmaceutical industry, however, their effect on the brain has hardly been studied. We assessed the effects of long-term consumption of 5-nm amorphous silicon dioxide nanoparticles (SiO₂-NPs) by Syrian hamsters infected with the trematodes Opisthorchis felineus on the hippocampus and frontal cortex. Spectroscopic determination of brain neurometabolites, performed using a horizontal Magnetic Resonance Imaging system at 11.7 Tesla magnetic field, has shown that the ratio of the excitatory neurotransmitters (glutamate + glutamine + aspartate) to the inhibitory ones (GABA + glycine) was higher in the animals infected with O. felineus. However, pre-consumption of the SiO₂-NPs solution prevented this imbalance. In addition, the protective effect of SiO₂-NPs on the level of myo-inositol and glycine was found. It is concluded that the use of SiO₂-NPs can neutralize the negative effects of infectious factors on the brain.

中文翻译：

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二氧化硅纳米颗粒对猫瘟猫感染的叙利亚仓鼠的影响：1 H MRS脑研究

摘要

近年来，二氧化硅纳米粒子已广泛用于医学和制药行业，但是，其对大脑的作用尚未得到研究。我们评估了感染海藻Opisthorchis felineus的叙利亚仓鼠长期食用5 nm纳米二氧化硅纳米颗粒（SiO ₂ -NPs）对海马和额叶皮层的影响。使用水平磁共振成像系统在11.7特斯拉磁场下对脑神经代谢物进行光谱测定，结果表明，动物中兴奋性神经递质（谷氨酸+谷氨酰胺+天冬氨酸）与抑制性神经递质（GABA +甘氨酸）的比例更高。感染猫科动物。但是，SiO的预消耗₂ -NPs解决方案防止了这种不平衡。另外，发现了SiO ₂ -NPs对肌醇和甘氨酸水平的保护作用。结论是，使用SiO ₂ -NPs可以抵消传染因子对大脑的负面影响。