People who inject drugs (PWID) face barriers to engagement in antiretro-viral treatment (ART) and medication-assisted treatment (MAT). We detail the design, rapid preparation and adaptation, and systematic implementation of a flexible, individually tailored intervention for PWID in multiple settings: Indonesia, Ukraine, and Vietnam. HPTN 074 integrated systems navigation and counseling to facilitate entry and adherence to ART and MAT. Site-level guidance on the intervention involved in-depth interviews (IDIs) among PWID and their supporters and site-specific document review. IDIs emphasized ART misinformation and importance of social support for adherence. The document review revealed differences in health care system barriers, requiring an intervention that was flexible and tailored enough to address key outcomes. Implementation included regular debriefs for iterative adaptations based on participants' needs, including booster counseling sessions and subsidizing pre-ART testing. HPTN 074 provides a unique framework implementing a flexible and scalable intervention to improve ART and MAT outcomes among PWID across multiple settings.

中文翻译：

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设计个性化的多层次干预措施，以增加在注射HIV药物的人群中对HIV和药物使用治疗的参与度：HPTN 074

注射药物（PWID）的人在参与抗逆转录病毒治疗（ART）和药物辅助治疗（MAT）方面面临障碍。我们详细介绍了针对印度尼西亚，乌克兰和越南等多种环境的PWID的灵活，个性化干预措施的设计，快速准备和改编以及系统实施。HPTN 074集成了系统导航和咨询功能，以促进进入和遵守ART和MAT。在干预方面的站点级别指导涉及PWID及其支持者之间的深入访谈（IDI），以及特定于站点的文档审查。IDI强调ART错误信息和社会支持对依从性的重要性。文件审查揭示了医疗保健系统壁垒的差异，需要采取灵活且针对性强的干预措施以解决关键结果。实施包括定期根据参与者的需要进行汇报，以适应参与者的需求，包括加强咨询会议和资助ART之前的测试。HPTN 074提供了一个独特的框架，该框架实施了灵活且可扩展的干预措施，以跨多个设置改善PWID之间的ART和MAT结果。