Since WHO released the first PrEP guidance in 2012, the PrEP research literature has rapidly increased, but PrEP uptake is still low. To identify research gaps, this scoping review describes study characteristics, identifies populations, and maps study topics in PrEP publications. We identified 561 PrEP primary studies published in English between 2006 and 2018. The most commonly used study design was cross-sectional. Almost half of studies were conducted in non-U.S. countries and focused on men who have sex with men. We mapped study topics using five categories. The most studied category was Potential PrEP user/prescriber (41.3%) followed by Considerations while on PrEP (28.2%), PrEP efficacy and safety (20.9%), Cost-effectiveness or economic evaluation (5.2%), and Methods of and experiences with PrEP clinical trials (4.2%). Although the PrEP literature has dramatically increased, some research areas (e.g., PrEP awareness in non-U.S. countries, intervention studies to promote PrEP use) and populations (e.g., Black women) are still understudied.

中文翻译：

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绘制艾滋病毒暴露前预防研究文献的研究特征和主题：范围概述

自世界卫生组织于2012年发布第一份PrEP指南以来，PrEP研究文献迅速增加，但PrEP吸收率仍然很低。为了确定研究差距，本范围界定性研究描述了研究特征，确定了种群并绘制了PrEP出版物中的研究主题。我们确定了2006年至2018年之间以英文发表的561篇PrEP小学研究。最常用的研究设计是横断面研究。几乎一半的研究是在非美国国家/地区进行的，研究重点是与男性发生性关系的男性。我们使用五个类别来映射研究主题。研究最多的类别是潜在的PrEP用户/处方者（41.3％），其次是PrEP的注意事项（28.2％），PrEP的有效性和安全性（20.9％），成本效益或经济评估（5.2％），以及使用方法和经验进行PrEP临床试验（4.2％）。