We tested the acceptability, feasibility, and preliminary efficacy of Our Family Our Future, a resilience-oriented intervention engaging families in prevention of adolescent HIV and depression. South African adolescents, 13-15 years of age, with mild depressive symptoms, were randomized to intervention or wait-list using parallel assignment in a single-blind trial. HIV risk behavior and depression were evaluated at baseline, 1, and 3 months. We examined intervention satisfaction, fidelity, trial retention, and preliminary efficacy. One hundred-ninety-six adolescent-parent dyads completed eligibility screening and baseline, and n = 73 dyads were randomized. All families ranked intervention quality as good or excellent. Over 90% were satisfied with content. Facilitators were adherent to intervention protocol. All families were retained in post-intervention assessments. Intervention recipients reported diminished depressive symptoms, inconsistent condom use, and sexual activity, as well as increased HIV testing. Our Family Our Future is highly acceptable and feasible and should be tested in a future efficacy trial.

中文翻译：

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以适应力为导向的家庭干预措施预防青少年艾滋病毒和抑郁的可接受性，可行性和初步功效：一项随机对照试验

我们测试了“我们的家庭我们的未来”的可接受性，可行性和初步功效，这是一种以韧性为导向的干预措施，旨在让家庭参与预防青少年HIV和抑郁症。在单盲试验中，使用平行分配将13-15岁，患有轻度抑郁症状的南非青少年随机分配至干预或等候名单。在基线，1、3个月时评估了HIV风险行为和抑郁。我们检查了干预的满意度，保真度，试验保留率和初步疗效。一百九十六个青少年父母双胞胎完成了资格筛选和基线，并且将n = 73个双胞胎随机分组。所有家庭都将干预质量评为好或优秀。超过90％的人对内容感到满意。主持人遵守干预方案。所有家庭均接受干预后评估。干预接受者报告抑郁症状减轻，安全套使用不一致，性行为减少以及艾滋病毒检测增加。我们的家庭我们的未来是高度可接受且可行的，应在以后的功效试验中进行测试。