AIM Deficits in synchronous, gamma-frequency neural oscillations may contribute to schizophrenia patients' real-world functional impairment and can be measured electroencephalographically using the auditory steady-state response (ASSR). Gamma ASSR deficits have been reported in schizophrenia patients and individuals at clinical high risk (CHR) for developing psychosis. We hypothesized that, in CHR patients, gamma ASSR would correlate with real-world functioning, consistent with a role for gamma synchrony deficits in functional impairment. METHODS A total of 35 CHR patients rated on Global Functioning: Social and Role scales had EEG recorded while listening to 1-ms, 93-dB clicks presented at 40 Hz in 500-ms trains, in response to which 40-Hz evoked power and intertrial phase-locking factor (PLF) were measured. RESULTS In CHR patients, lower 40-Hz PLF correlated with lower social functioning. CONCLUSIONS Gamma synchrony deficits may be a biomarker of real-world impairment at early stages of the schizophrenia disease trajectory.

中文翻译：

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临床高危精神病患者未接受药物治疗时，伽马听觉稳态反应降低与现实世界功能受损有关

AIM 同步、伽马频率神经振荡的缺陷可能导致精神分裂症患者的现实世界功能障碍，并且可以使用听觉稳态响应 (ASSR) 进行脑电图测量。据报道，在精神分裂症患者和处于临床高危 (CHR) 发展为精神病的个体中，伽马 ASSR 缺陷。我们假设，在 CHR 患者中，伽马 ASSR 将与现实世界的功能相关，与伽马同步缺陷在功能障碍中的作用一致。方法 共有 35 名在全球功能：社会和角色量表上评分的 CHR 患者记录了脑电图，同时在 500 毫秒的火车中以 40 赫兹呈现 1 毫秒、93 分贝的咔嗒声，作为响应，40 赫兹诱发了功率和测量了试验间锁相因子（PLF）。结果 在 CHR 患者中，较低的 40-Hz PLF 与较低的社会功能相关。结论 伽马同步缺陷可能是精神分裂症疾病轨迹早期真实世界损伤的生物标志物。