Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In light of significant differences in ROS levels between the nonpathogenic and pathological tissues, an increasing number of ROS-responsive prodrugs, probes, and theranostic prodrugs have been developed for the targeted treatment and precise diagnosis of ROS-related diseases. This review will summarize and provide insight into recent advances in ROS-responsive prodrugs, fluorescent probes, and theranostic prodrugs, with applications to different ROS-related diseases and various subcellular organelle-targetable and disease-targetable features. The ROS-responsive moieties, the self-immolative linkers, and the typical activation mechanism for the ROS-responsive release are also summarized and discussed.

中文翻译：

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活性氧（ROS）响应性前药，探针和治疗性前药：在ROS相关疾病中的应用

活性氧（ROS）水平升高通常与多种疾病有关，包括癌症，炎症和神经退行性疾病。鉴于非致病组织和病理组织之间的ROS水平存在显着差异，已开发出越来越多的ROS反应性前药，探针和治疗性前药用于ROS相关疾病的靶向治疗和精确诊断。这篇综述将总结并提供ROS响应前药，荧光探针和治疗诊断前药的最新进展，并应用于不同的ROS相关疾病以及以亚细胞器为靶标和以疾病为靶标的各种功能。ROS响应部分，自焚连接子