A facile and green method was explored to prepare the tetracycline hydrochloride- (TCH-) loaded poly (ε-caprolactone)-chitosan-silica xerogel (PCL-CS-SiO₂) hybrid fibers by using 90% acetic acid as a suitable solvent. The SEM results showed that those fibers exhibited a continuous, bead-free morphology, an average diameter of about 430 nm, and super-hydrophilicity (). The presence of SiO₂ was found to enhance the thermal stability of the hybrid fibers, and the actual content of SiO₂ was obtained by the TG measurement. Moreover, SiO₂ xerogel as an important bioceramic endowed the hybrid fibers with good drug release behavior and in vitro bioactivity, suggesting their potential use as novel drug carriers for bone tissue engineering. The present work is expected to offer a green strategy to develop novel, multifunctional hybrid materials.

中文翻译：

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开发用于生物医学应用的新型含药聚（ε-己内酯）-壳聚糖-二氧化硅干凝胶混合纤维的绿色战略

探索了一种简便，绿色的方法，以90％的乙酸为溶剂，制备了负载四环素盐酸盐（TCH-）的聚（ε-己内酯）-壳聚糖-硅胶干凝胶（PCL-CS-SiO ₂）杂化纤维。SEM结果表明，这些纤维表现出连续无珠的形态，平均直径约为430 nm，并且具有超亲水性（）。发现SiO ₂的存在增强了杂化纤维的热稳定性，并且通过TG测量获得了SiO ₂的实际含量。此外，SiO ₂干凝胶作为一种重要的生物陶瓷赋予了杂化纤维良好的药物释放性能和体外生物活性，表明它们潜在地用作骨组织工程的新型药物载体。预期当前的工作将为开发新型多功能混合材料提供绿色战略。