Background. Urinary tract infection is one of the most common bacterial infections encountered in pregnant women with significant morbidity. This study aimed to determine the bacterial profile and its antimicrobial susceptibility pattern of urinary tract infection among pregnant women attending antenatal care (ANC) at a Hawassa University Comprehensive Specialized Hospital (HUCSH), Southern Ethiopia. Method. A cross-sectional study was conducted in which consecutive pregnant women enrolled in the study from March to June 2019. The structured questionnaire used to collect sociodemographic and clinical data in a face-to-face interview. Midstream urine was collected from pregnant women using sterile containers. Culture and sensitivity were performed using a standard operating procedure of the microbiology laboratory. Data entry and analysis were conducted using the statistical package for social sciences (SPSS) version 20. Descriptive and logistic regression was used to conduct the output of the data. The odds ratio at 95% confidence interval was considered as a statistically significant association with a value <0.05. Result. The overall magnitude of urinary tract infection in this study was 7.8% (4.7–10.8%). Escherichia coli was found to be the most frequently isolated (47.8%), followed by Klebsiella pneumoniae (17.4%), Staphylococcus aureus (8.7%), Klebsiella ozaenae, Klebsiella rhinoscleromatis, Citrobacter spp., Salmonella group A, Staphylococcus saprophyticus, and Enterobacter cloacae each (4.3%). Gram-negative bacteria were sensitive to 78.3%, 91.3%, and 100% of ciprofloxacin, gentamicin, and nitrofurantoin, respectively. Gram-positive bacteria were sensitive to clindamycin (100%), gentamicin (100%), and nitrofurantoin (100%) and fully resistant to ceftriaxone (100%) and cefuroxime (100%). There is no statistically significant association (p < 0.05) between the risk factor of urinary tract infection and UTI. Conclusion. The overall prevalence of urinary tract infection among pregnant women attending antenatal care was 7.8%. Escherichia coli were the dominant isolate followed by Klebsiella pneumoniae. Gram-negative isolates are highly sensitive to ciprofloxacin, gentamicin, nitrofurantoin, and ceftriaxone and Gram-positive isolates to gentamicin, clindamycin, and nitrofurantoin. Most of the bacteria are resistant to cotrimoxazole and cefuroxime. There is no statistically significantly associated variable. Screening for the presence of urinary tract infection during pregnancy will improve the quality of antenatal care further reducing complication. The above antibiotics can be prescribed based on the side effect to pregnant women in case empirical treatment is mandatory in the study area.

中文翻译：

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埃塞俄比亚南部一家三级医院接受产前检查的孕妇尿路感染的细菌特征和抗生素敏感性模式

背景。尿路感染是孕妇最常见的细菌感染之一，发病率很高。本研究旨在确定在埃塞俄比亚南部哈瓦萨大学综合专科医院 (HUCSH) 接受产前保健 (ANC) 的孕妇中尿路感染的细菌谱及其抗菌药物敏感性模式。方法. 进行了一项横断面研究，其中连续的孕妇在 2019 年 3 月至 2019 年 6 月期间参加了该研究。结构化问卷用于在面对面访谈中收集社会人口学和临床数据。使用无菌容器从孕妇中收集中段尿液。使用微生物实验室的标准操作程序进行培养和敏感性。使用社会科学统计软件包 (SPSS) 第 20 版进行数据输入和分析。使用描述性和逻辑回归进行数据输出。95% 置信区间的优势比被认为是具有统计学意义的关联，其值 <0.05。结果. 本研究中尿路感染的总体规模为 7.8% (4.7–10.8%)。大肠杆菌被发现是最常分离的（47.8%），其次是肺炎克雷伯菌（17.4%）、金黄色葡萄球菌（8.7%）、克雷伯菌、鼻硬化克雷伯菌、柠檬酸杆菌属、沙门氏菌A组、腐生葡萄球菌和肠杆菌泄殖腔每个 (4.3%)。革兰氏阴性菌对环丙沙星、庆大霉素和呋喃妥因的敏感性分别为 78.3%、91.3% 和 100%。革兰氏阳性菌对克林霉素（100%）、庆大霉素（100%）和呋喃妥因（100%）敏感，对头孢曲松（100%）和头孢呋辛（100%）完全耐药。 尿路感染危险因素与尿路感染之间无统计学显着相关性（p <0.05）。结论。接受产前检查的孕妇尿路感染的总体患病率为 7.8%。大肠杆菌是主要的分离菌，其次是肺炎克雷伯菌。革兰氏阴性菌对环丙沙星、庆大霉素、呋喃妥因和头孢曲松高度敏感，革兰氏阳性菌对庆大霉素、克林霉素和呋喃妥因高度敏感。大多数细菌对复方新诺明和头孢呋辛具有抗药性。没有统计学上显着相关的变量。在怀孕期间筛查是否存在尿路感染将提高产前保健的质量，进一步减少并发症。如果研究区域内必须进行经验性治疗，可根据对孕妇的副作用开具上述抗生素。