HLA genes play a pivotal role in an immune response via the presentation of pathogen peptides in a complex on the surface of cells of a host organism. Here, we studied the association of class I and class II genes with the severity of COVID-19 infection and HLA allele variants. We performed high-resolution sequencing of class I and class II HLA genes using the sample population of 147 patients who died of COVID-19 and statistically compared our results with the frequencies of the HLA genotypes in a control population of 270 samples. The obtained data demonstrated that 51:05 and 15:18 alleles from locus B* are statistically significantly associated with COVID-19 severity, while C*14:02 allele correlates with the probability of death from COVID-19 for patients without comorbidities.

中文翻译：

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俄罗斯人群中HLA等位基因与COVID-19相关死亡率的关联性搜寻

HLA基因通过在宿主生物体细胞表面复合物中呈递病原体肽而在免疫反应中发挥关键作用。在这里，我们研究了I类和II类基因与COVID-19感染和HLA等位基因变异的严重程度之间的关系。我们对147名死于COVID-19的患者进行了I类和II类HLA基因的高分辨率测序，并对我们的结果与270个样本对照组中HLA基因型的频率进行了统计学比较。获得的数据表明，来自基因座B *的51:05和15:18等位基因与COVID-19严重程度在统计学上显着相关，而对于没有合并症的患者，C * 14：02等位基因与因COVID-19死亡的可能性相关。