Acute anorexia nervosa (AN) constitutes an extreme physiological state. We aimed to detect state related metabolic alterations during inpatient admission and upon short- and long-term weight regain. In addition, we tested the hypothesis that metabolite concentrations adapt to those of healthy controls (HC) after long-term weight regain. Thirty-five female adolescents with AN and 25 female HC were recruited. Based on a targeted approach 187 metabolite concentrations were detected at inpatient admission (T₀), after short-term weight recovery (T₁; half of target-weight) and close to target weight (T₂). Pattern hunter and time course analysis were performed. The highest number of significant differences in metabolite concentrations (N = 32) were observed between HC and T₁. According to the detected main pattern, metabolite concentrations at T₂ became more similar to those of HC. The course of single metabolite concentrations (e.g., glutamic acid) revealed different metabolic subtypes within the study sample. Patients with AN after short-term weight regain are in a greater “metabolic imbalance” than at starvation. After long-term weight regain, patients reach a metabolite profile similar to HC. Our results might be confounded by different metabolic subtypes of patients with AN.

中文翻译：

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住院，短期和长期体重恢复期间神经性厌食症患者代谢谱的评估-描述和模式分析

急性神经性厌食症（AN）构成一种极端的生理状态。我们旨在检测住院期间以及短期和长期体重恢复中与状态相关的代谢变化。此外，我们测试了长期体重恢复后代谢物浓度适应健康对照组（HC）的假设。招募了35名患有AN的女性青少年和25名女性HC。根据目标方法，在短期体重恢复（T ₁；目标体重的一半）且接近目标体重（T ₂）后，入院时（T ₀）检测到了187种代谢物浓度）。进行模式猎手和时程分析。HC和T ₁之间的代谢物浓度差异最大（N = 32）。根据检测到的主要模式，T ₂处的代谢物浓度变得与HC更为相似。单一代谢物浓度（例如谷氨酸）的变化过程揭示了研究样品中不同的代谢亚型。短期体重减轻后患有AN的患者比饥饿时处于更大的“代谢失衡”状态。长期减轻体重后，患者的代谢产物与HC相似。我们的结果可能与AN患者的不同代谢亚型混淆。