Self-Assembly of Solubilized Human Hair Keratins,ACS Biomaterials Science & Engineering

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Self-Assembly of Solubilized Human Hair Keratins
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-23 , DOI: 10.1021/acsbiomaterials.0c01507
Hui Ying Lai _{1,

2} , Magdiel Inggrid Setyawati ₁ , Abdul Rahim Ferhan ₁ , Shiva Kamini Divakarla ₃ , Huei Min Chua ₁ , Nam-Joon Cho ₁ , Wojciech Chrzanowski ₃ , Kee Woei Ng _{1,

2,

4,

5}

Affiliation

Human hair keratins have proven to be a viable biomaterial for diverse regenerative applications. However, the most significant characteristic of this material, the ability to self-assemble into nanoscale intermediate filaments, has not been exploited. Herein, we successfully demonstrated the induction of hair-extracted keratin self-assembly in vitro to form dense, homogeneous, and continuous nanofibrous networks. These networks remain hydrolytically stable in vitro for up to 5 days in complete cell culture media and are compatible with primary human dermal fibroblasts and keratinocytes. These results enhance the versatility of human hair keratins for applications where structured assembly is of benefit.

中文翻译：

可溶性人发角蛋白的自组装

人发角蛋白已被证明是用于多种再生应用的可行生物材料。然而，这种材料的最显着特征是自组装成纳米级中间丝的能力尚未得到开发。在这里，我们成功地证明了体外诱导头发提取的角蛋白自组装形成致密，均匀和连续的纳米纤维网络。这些网络在完整的细胞培养基中可在体外保持长达5天的水解稳定性，并且与原代人皮肤成纤维细胞和角质形成细胞兼容。这些结果增强了人发角蛋白在结构化组装有益的应用中的多功能性。

更新日期：2021-01-11

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