ABSTRACT

Objectives: Traumatic brain injury (TBI) is an increasingly significant health concern worldwide, compounded by the difficultly in detection and diagnosis. Fortunately, a growing body of research has identified oculomotor behavior, specifically fixations, saccades and smooth pursuit eye movements as a promising endophenotype for neurotrauma. To date, limited research exists using fixation stability in a comparative study to indicate the presence of a mild TBI (mTBI), especially in the pediatric population.Methods: The present study examined data from 91 individuals clinically diagnosed with mTBI and a further 140 age- and gender-matched controls. They all completed the RightEye fixation stability test using a remote eye tracker. Participants were compared on five fixation metrics: Bivariate Contour Ellipse Area (BCEA), Convergence Point, Depth, Disassociated Phoria, and Targeting Displacement.Results: Results were analyzed using one-way univariate ANOVAs, ROC analysis, and stepwise logistic regression. BCEA results revealed significant differences between groups with the mTBI group showing a larger gaze spread, indicative of less ability to keep the eyes close to the target without deviating.Conclusions: Fixation stability is detrimentally impacted by mTBI in pediatric patients, and the oculomotor test can be used to differentiate between those with and without an mTBI.

摘要

目的：外伤性脑损伤 (TBI) 是世界范围内日益严重的健康问题，检测和诊断的困难使情况更加复杂。幸运的是，越来越多的研究已经确定动眼神经行为，特别是注视、扫视和平滑的眼球运动，是神经创伤的一种有前途的内表型。迄今为止，在比较研究中使用固定稳定性来表明存在轻度 TBI (mTBI) 的研究有限，尤其是在儿科人群中。 - 和性别匹配的控制。他们都使用远程眼动仪完成了 RightEye 固视稳定性测试。参与者在五个注视指标上进行了比较：双变量轮廓椭圆面积 (BCEA)、收敛点、深度、分离的隐匿性隐匿症和靶向位移。结果：使用单向单变量方差分析、ROC 分析和逐步逻辑回归分析结果。BCEA 结果显示组间存在显着差异，mTBI 组显示出更大的视线扩散，表明在不偏离的情况下保持眼睛靠近目标的能力较低。用于区分有和没有 mTBI 的患者。