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Fixation stability as a biomarker for differentiating mild traumatic brain injury from age matched controls in pediatrics
Brain Injury ( IF 1.5 ) Pub Date : 2020-12-24 , DOI: 10.1080/02699052.2020.1865566
Melissa Hunfalvay 1 , Nicholas P Murray 2 , Frederick Robert Carrick 3, 4, 5
Affiliation  

ABSTRACT

Objectives: Traumatic brain injury (TBI) is an increasingly significant health concern worldwide, compounded by the difficultly in detection and diagnosis. Fortunately, a growing body of research has identified oculomotor behavior, specifically fixations, saccades and smooth pursuit eye movements as a promising endophenotype for neurotrauma. To date, limited research exists using fixation stability in a comparative study to indicate the presence of a mild TBI (mTBI), especially in the pediatric population.Methods: The present study examined data from 91 individuals clinically diagnosed with mTBI and a further 140 age- and gender-matched controls. They all completed the RightEye fixation stability test using a remote eye tracker. Participants were compared on five fixation metrics: Bivariate Contour Ellipse Area (BCEA), Convergence Point, Depth, Disassociated Phoria, and Targeting Displacement.Results: Results were analyzed using one-way univariate ANOVAs, ROC analysis, and stepwise logistic regression. BCEA results revealed significant differences between groups with the mTBI group showing a larger gaze spread, indicative of less ability to keep the eyes close to the target without deviating.Conclusions: Fixation stability is detrimentally impacted by mTBI in pediatric patients, and the oculomotor test can be used to differentiate between those with and without an mTBI.



中文翻译:

固定稳定性作为区分轻度创伤性脑损伤与儿科年龄匹配对照的生物标志物

摘要

目的:外伤性脑损伤 (TBI) 是世界范围内日益严重的健康问题,检测和诊断的困难使情况更加复杂。幸运的是,越来越多的研究已经确定动眼神经行为,特别是注视、扫视和平滑的眼球运动,是神经创伤的一种有前途的内表型。迄今为止,在比较研究中使用固定稳定性来表明存在轻度 TBI (mTBI) 的研究有限,尤其是在儿科人群中。 - 和性别匹配的控制。他们都使用远程眼动仪完成了 RightEye 固视稳定性测试。参与者在五个注视指标上进行了比较:双变量轮廓椭圆面积 (BCEA)、收敛点、深度、分离的隐匿性隐匿症和靶向位移。结果:使用单向单变量方差分析、ROC 分析和逐步逻辑回归分析结果。BCEA 结果显示组间存在显着差异,mTBI 组显示出更大的视线扩散,表明在不偏离的情况下保持眼睛靠近目标的能力较低。用于区分有和没有 mTBI 的患者。

更新日期:2020-12-24
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