Abstract

A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2–13), were isolated from the South China Sea soft coral Sinularia humilis. Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound 11 exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC₅₀ value of 12.5 µM.

中文翻译：

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南海软珊瑚Sinularia humilis的化学成分

摘要

从南海软珊瑚Sinularia humilis中分离出一种具有不寻常的二萜骨架的新二萜类化合物 sinuhumilol A ( 1 )，以及十二种已知的不同化合物 ( 2-13 )。通过广泛的光谱分析、量子化学计算和/或通过将光谱数据与文献中报道的数据进行比较，阐明了它们的结构和立体化学。在生物测定中，化合物11对人结肠腺癌细胞系 HT-29 表现出有趣的特异性细胞毒性，IC ₅₀值为 12.5  µM。