Proteomic Approaches to Investigate Regulated Trafficking and Signaling of G Protein–Coupled Receptors,Molecular Pharmacology

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Proteomic Approaches to Investigate Regulated Trafficking and Signaling of G Protein–Coupled Receptors
Molecular Pharmacology ( IF 3.2 ) Pub Date : 2021-05-01 , DOI: 10.1124/molpharm.120.000178
Mark von Zastrow ₁

Affiliation

Advances in proteomic methodologies based on quantitative mass spectrometry are now transforming pharmacology and experimental biology more broadly. The present review will discuss several examples based on work in the author’s laboratory, which focuses on delineating relationships between G protein–coupled receptor signaling and trafficking in the endocytic network. The examples highlighted correspond to those discussed in a talk presented at the 2019 EB/ASPET meeting, which was organized by Professor Joe Beavo to commemorate his receipt of the Julius Axelrod Award.

中文翻译：

研究 G 蛋白偶联受体的受管制贩运和信号传导的蛋白质组学方法

基于定量质谱的蛋白质组学方法的进步现在正在更广泛地改变药理学和实验生物学。本综述将根据作者实验室的工作讨论几个例子，重点描述 G 蛋白偶联受体信号传导与内吞网络中的运输之间的关系。突出显示的示例与 2019 年 EB/ASPET 会议上的演讲中讨论的示例相对应，该会议由 Joe Beavo 教授组织，以纪念他获得 Julius Axelrod 奖。

更新日期：2021-04-16

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