Adaptive behavior in response to adverse experiences facilitates faster recovery and less time spent engaging in maladaptive behaviors that contribute to psychopathology, including anxiety, depression, and post-traumatic stress disorder. Dysregulation of activity in the prefrontal cortex (PFC) has been implicated in these disorders, as well as in diminished cognitive flexibility, with stress further exacerbating these negative effects. Corticotropin-releasing factor is an important regulator of the stress-response system and may have a differential involvement in individuals who are especially susceptible to negative stress-related outcomes. A recent study by Chen et al. (Neuron 106: 301-315, 2020) has identified a novel subtype of GABAergic CRF interneurons in the dorsomedial PFC that, upon activation, can promote active responses and resilient behavior in response to stress.

中文翻译：

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背内侧前额叶皮质中的抑制性促肾上腺皮质激素释放因子神经元促进雄性啮齿动物的抗应激行为

应对不良经历的适应性行为有助于更快地恢复，并减少用于导致精神病理学的适应不良行为的时间，包括焦虑、抑郁和创伤后应激障碍。前额叶皮层 (PFC) 活动的失调与这些疾病有关，以及认知灵活性降低，压力进一步加剧了这些负面影响。促肾上腺皮质激素释放因子是压力反应系统的重要调节因子，可能对特别容易受到负面压力相关结果影响的个体有不同的参与。Chen 等人最近的一项研究。(Neuron 106: 301-315, 2020) 已经确定了背内侧 PFC 中 GABAergic CRF 中间神经元的一种新亚型，在激活后，