BACKGROUND The published evidences on the correlations of toll-like receptor 4 (TLR4) and TLR9 gene polymorphisms and ankylosing spondylitis (AS) were conflicting. The purpose of this study was to investigate whether TLR4 and TLR9 gene polymorphisms conferred susceptibility to AS through a meta-analysis approach. METHODS Databases of PubMed, Web of Science, EMBASE, Cochrane Library, CNKI and Wanfang were retrieved for relevant publications up to 20 June 2020. Study quality was assessed based on Newcastle-Ottawa scale (NOS). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to judge the associations. RESULTS Totally, 13 articles with 3,055 AS cases and 4,238 controls were incorporated into this meta-analysis, and four most widely reported polymorphisms (TLR4-rs4986790, TLR4-rs4986791, TLR9-rs55704465 and TLR9-rs187084) were analysed. All included studies were in high quality. The pooled data did not support any significant association between the four studied polymorphisms and AS susceptibility. CONCLUSIONS The present meta-analysis suggests there is no significant association between TLR4-rs4986790, TLR4-rs4986791, TLR9-rs55704465 and TLR9-rs187084 polymorphisms and AS.

中文翻译：

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Toll 样受体 4 和 2 基因多态性与强直性脊柱炎易感性的关联：荟萃分析

背景 已发表的关于 Toll 样受体 4 (TLR4) 和 TLR9 基因多态性与强直性脊柱炎 (AS) 相关性的证据相互矛盾。本研究的目的是通过荟萃分析方法研究 TLR4 和 TLR9 基因多态性是否赋予 AS 易感性。方法检索截至 2020 年 6 月 20 日的 PubMed、Web of Science、EMBASE、Cochrane Library、CNKI 和万方数据库的相关出版物。根据纽卡斯尔-渥太华量表 (NOS) 评估研究质量。优势比 (OR) 和 95% 置信区间 (95% CI) 用于判断关联。结果 本次荟萃分析共纳入 13 篇文章，其中 3,055 例 AS 病例和 4,238 例对照，以及 4 个最广泛报道的多态性（TLR4-rs4986790、TLR4-rs4986791、TLR9-rs55704465 和 TLR9-rs187084) 进行了分析。所有纳入的研究都是高质量的。汇总数据不支持四个研究的多态性与 AS 易感性之间的任何显着关联。结论 本荟萃分析表明 TLR4-rs4986790、TLR4-rs4986791、TLR9-rs55704465 和 TLR9-rs187084 多态性与 AS 之间没有显着关联。