MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis,Neuropathology and Applied Neurobiology

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MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2020-12-23 , DOI: 10.1111/nan.12688
Conceição Bettencourt _{1,

2} , Yasuo Miki _{1,

3} , Ignazio S Piras ₄ , Rohan de Silva _{2,

5} , Sandrine C Foti _{1,

6} , Joshua S Talboom ₄ , Tamas Revesz _{1,

5,

6} , Tammaryn Lashley _{1,

6} , Robert Balazs _{1,

6} , Emmanuelle Viré ₇ , Thomas T Warner _{1,

2,

5} , Matt J Huentelman ₄ , Janice L Holton _{1,

2}

Affiliation

Multiple system atrophy (MSA) is a fatal neurodegenerative disease. Similar to Parkinson's disease (PD), MSA is an α-synucleinopathy, and its pathological hallmark consists of glial cytoplasmic inclusions (GCIs) containing α-synuclein (SNCA) in oligodendrocytes. We previously identified consistent changes in myelin-associated oligodendrocyte basic protein (MOBP) and huntingtin interacting protein 1 (HIP1) DNA methylation status in MSA. We hypothesized that if differential DNA methylation at these loci is mechanistically relevant for MSA, it should have downstream consequences on gene regulation.

中文翻译：

多系统萎缩中的 MOBP 和 HIP1：神经胶质细胞质内含物中的新 α-突触核蛋白伙伴与疾病发病机制有关

多系统萎缩（MSA）是一种致命的神经退行性疾病。与帕金森病（PD）类似，MSA是一种α-突触核蛋白病，其病理特征是少突胶质细胞中含有α-突触核蛋白（SNCA）的胶质细胞质包涵体（GCI）。我们之前发现 MSA 中髓磷脂相关少突胶质细胞碱性蛋白 ( MOBP ) 和亨廷顿蛋白相互作用蛋白 1 ( HIP1 ) DNA 甲基化状态的一致变化。我们假设，如果这些位点的差异 DNA 甲基化在机制上与 MSA 相关，那么它应该对基因调控产生下游影响。

更新日期：2020-12-23

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