Circulation of an atypical hepatitis C virus (HCV) strain at a dialysis unit in northeast India,MicrobiologyOpen

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Circulation of an atypical hepatitis C virus (HCV) strain at a dialysis unit in northeast India
MicrobiologyOpen ( IF 3.9 ) Pub Date : 2020-12-24 , DOI: 10.1002/mbo3.1147
Deepjyoti Kalita _{1,

2} , Sangeeta Deka ₁ , Kailash Chamuah ₂

Affiliation

Patients undergoing hemodialysis are at an increased risk of hepatitis C virus (HCV) infection. The implementation of standard infection control measures can substantially decrease the risk of infections and other nosocomial infections. To study the HCV infection rates and genotypes in maintenance hemodialysis subjects in a dialysis unit. A total of 196 maintenance hemodialysis subjects were tested for HCV RNA for one year at a tertiary care teaching hospital in northeast India continuously. Genotyping was performed using direct sequencing (Sanger sequencing) of the 5′UTR‐core region. The HCV infection rate was 26.0%. On phylogenetic analysis, 29 sequences clustered around genotype 3 and subtype 3f were observed. High sequence similarities (75–100% homology) were observed among the isolated sequences. High molecular similarities in the isolates from the same dialysis unit with a high infection rate (26.0%) over a relatively short period of study (10 months) indicated an ongoing nosocomial transmission. Nosocomial transmission by subtype 3f is rare, and it has not been reported in dialysis cases previously. The strain is most likely evolving from common strains such as 3b or 3i and may spread due to migration or movement of people. Urgent implementation of adequate infection control measures is required.

中文翻译：

印度东北部一个透析单位的非典型丙型肝炎病毒 (HCV) 株的循环

接受血液透析的患者感染丙型肝炎病毒 (HCV) 的风险增加。标准感染控制措施的实施可以大大降低感染和其他医院感染的风险。研究透析室维持性血液透析受试者的 HCV 感染率和基因型。在印度东北部的一家三级护理教学医院，对总共 196 名维持性血液透析受试者进行了为期一年的 HCV RNA 连续检测。使用 5'UTR 核心区域的直接测序（Sanger 测序）进行基因分型。HCV感染率为26.0%。在系统发育分析中，观察到聚集在基因型 3 和亚型 3f 周围的 29 个序列。在分离的序列中观察到高序列相似性（75-100% 同源性）。在相对较短的研究期间（10 个月），来自同一透析单位的高感染率（26.0%）的分离株的高分子相似性表明持续的医院传播。3f 亚型的院内传播很少见，以前在透析病例中未见报道。该菌株很可能是从 3b 或 3i 等常见菌株演变而来的，并且可能由于人员迁移或移动而传播。需要紧急实施适当的感染控制措施。该菌株很可能是从 3b 或 3i 等常见菌株演变而来的，并且可能由于人员迁移或移动而传播。需要紧急实施适当的感染控制措施。该菌株很可能是从 3b 或 3i 等常见菌株演变而来的，并且可能由于人员迁移或移动而传播。需要紧急实施适当的感染控制措施。

更新日期：2021-02-16

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