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Co‐infection of malaria and early clearance of SARS‐CoV‐2 in healthcare workers
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2020-12-24 , DOI: 10.1002/jmv.26760
Niraj N. Mahajan 1 , Rahul K. Gajbhiye 2 , Shubhada Bahirat 1 , Pradip D Lokhande 1 , Apeksha Mathe 1 , Surbhi Rathi 3 , Neeta Warty 1 , Kshitija N. Mahajan 4 , Vartika Srivastava 1 , Periyasamy Kuppusamy 2 , Shailesh C. Mohite 5
Affiliation  

Healthcare workers (HCWs) are at higher risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Information regarding co‐infection of SARS‐CoV‐2 with vector‐borne diseases (malaria and dengue) is crucial especially for the countries wherein malaria and dengue are endemic. The objective was to study the prevalence, demographic, clinical presentations among HCWs with coronavirus disease 2019 (COVID‐19) and to compare the viral clearance in HCWs with COVID‐19 and co‐infection of malaria and dengue. This retrospective study was conducted at a dedicated COVID‐19 hospital, BYL Nair Charitable Hospital (NH), Mumbai, India April 6th–October 31st 2020. The SARS‐CoV‐2 infection in HCWs was confirmed by reverse transcription‐plymerase chain reaction. Out of 491 HCWs infected with SARS‐CoV‐2, analysis of viral clearance was carried out in 467 HCWs over seven month periods, The prevalence of SARS‐CoV‐2 infection in HCWs was 13% (491 out of 3711). Out of the HCWs with COVID‐19, prevalence of SARS‐CoV‐2 infection was higher among security guards (25%) with 1% mortality. The co‐infection of malaria or dengue was reported in 31 HCWs (6.3%). The mean duration of virus clearance was longer (12 days) in symptomatic HCWs as compared to asymptomatic (8 days, p < .005). The recovery of SARS‐CoV‐2 infection in HCWs was faster (mean 8 days) with co‐infection of malaria than without malaria (p < .005). We recommend universal testing of HCWs, to optimize staffing levels during the current pandemic as HCWs are the most precious resource. There is a need to effectively implement standard protocols for prevention of vector‐borne diseases, especially in the hospital settings.

中文翻译:

医护人员的疟疾共感染和SARS-CoV-2的早期清除

医护人员(HCW)感染严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)的风险较高。关于SARS-CoV-2与媒介传播疾病(疟疾和登革热)的共同感染的信息至关重要,尤其是对于疟疾和登革热为流行病的国家。目的是研究2019年冠状病毒病(HCVID-19)的HCW的流行率,人口统计学,临床表现,并比较COVID-19的HCW的病毒清除率以及疟疾和登革热的共同感染情况。这项回顾性研究在印度孟买BYL Nair慈善医院(NH)的COVID-19专用医院(4月6日至2020年10月31日)进行。通过逆转录聚合酶链反应证实了HCW中的SARS-CoV-2感染。在491名感染SARS-CoV-2的医护人员中,在七个月的时间内对467名HCW进行了病毒清除率分析,在HCW中SARS-CoV-2感染的发生率为13%(3711名患者中有491名)。在具有COVID-19的HCW中,SARS-CoV-2感染的发生率在死亡率为1%的保安人员中为25%。据报告,有31名医护人员同时感染疟疾或登革热(6.3%)。有症状的HCW的平均病毒清除持续时间比无症状的平均清除时间(12天)长(12天),p  <.005)。合并感染疟疾的人群中,HCW中SARS-CoV-2感染的恢复要快于无疟疾(p  <.005)。我们建议对HCW进行通用测试,以优化当前大流行期间的人员配置水平,因为HCW是最宝贵的资源。有必要有效实施预防媒介传播疾病的标准方案,尤其是在医院环境中。
更新日期:2021-02-17
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