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Physical training and exercise in myasthenia gravis
Neuromuscular Disorders ( IF 2.7 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.nmd.2020.12.004
Nils Erik Gilhus 1
Affiliation  

Myasthenia gravis is characterized by muscle weakness and fatigue. As sustained muscle use increases the weakness, the value of physical training programs has previously been questioned. This is a review to clarify the safety and usefulness of systematic training in myasthenia gravis, based on a systematic search in available databases using the relevant key words. Ten intervention studies including 159 patients with generalized disease have been published regarding the effect of systematic physical training, three of them on respiratory muscles. Muscle strength improved, and in the majority of the studies also daily function and quality of life. The feeling of fatigue not directly related to actual muscle weakness was less influenced by physical training. Continuous training was necessary to maintain the improved function. Physical training and exercise are safe in myasthenia gravis. This can improve both muscle strength and daily function. Type and intensity of systematic training should be adapted in the individual patient. A minimum of 150 min of exercise per week is recommended for myasthenia gravis patients with mild and moderate disease.

中文翻译:

重症肌无力的体育锻炼

重症肌无力的特点是肌肉无力和疲劳。随着持续的肌肉使用增加了弱点,体能训练计划的价值之前曾受到质疑。这篇综述旨在阐明重症肌无力系统培训的安全性和有效性,基于使用相关关键词在可用数据库中进行系统搜索。10 项干预研究,包括 159 名全身性疾病患者,已经发表了关于系统体育锻炼的影响,其中三项对呼吸肌的影响。肌肉力量得到改善,在大多数研究中也改善了日常功能和生活质量。与实际肌肉无力没有直接关系的疲劳感受体育训练的影响较小。需要持续训练以保持改善的功能。体能训练和运动在重症肌无力中是安全的。这可以提高肌肉力量和日常功能。系统训练的类型和强度应根据患者个体进行调整。对于轻度和中度疾病的重症肌无力患者,建议每周至少运动 150 分钟。
更新日期:2020-12-01
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