This study investigated the changes in choline (Ch) and butyrylcholinesterase (BChE) in saliva in canine parvovirosis (CP) as a model of sepsis, and their correlations with these analytes in serum and with other markers of inflammation such as white blood cell count (WBC) and serum C-reactive protein (CRP). A total of 30 dogs with CP were sampled for saliva and serum at presentation, and 10 healthy puppies were also sampled as controls. Salivary Ch was higher in dogs with CP (P < 0.001) showing a positive correlation with CRP, whereas no differences were observed in salivary BChE. This is the first report in which Ch is measured in saliva of dogs and based in the results of this study, salivary Ch could be potentially used as biomarker of the severity of CP.

这项研究调查了犬细小病毒病（CP）唾液中胆碱（Ch）和丁酰胆碱酯酶（BChE）的变化（作为败血症的模型），以及它们与血清中这些分析物以及其他炎症标志物（如白细胞计数）的相关性（ WBC）和血清C反应蛋白（CRP）。在呈报时，总共对30只患有CP的狗进行了唾液和血清采样，还抽取了10只健康的幼犬作为对照。CP犬的唾液Ch较高（P  <0.001），与CRP呈正相关，而唾液BChE则无差异。这是第一份测量狗唾液中Ch的报告，根据这项研究的结果，唾液Ch可能被用作CP严重程度的生物标志物。