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Enhancement in serum (1–3)-β-D-glucan level by cutaneous alternariosis: A case report and literature review
Microbial Pathogenesis ( IF 3.3 ) Pub Date : 2020-12-24 , DOI: 10.1016/j.micpath.2020.104703
Zongyao Chen 1 , Yayun Jiang 1 , Dengchao Wang 1 , Mao Zheng 1 , Xiao Liu 1 , Chengliang Yuan 1
Affiliation  

Contamination with the fungus Alternaria spp. is often considered to have originated from laboratory sources, which occasionally causes infection in immunocompromised patients, termed as phaeohyphomycosis. Here, we have reported a case of cutaneous alternariosis caused by Alternaria alternata. This diagnosis was based on microscopic examination and mycological culturing of patient's vesicular lesions, with the use of 5 molecular markers (namely, ITS, ATPase, Actin, rpb2, and tef1) for strain identification. We noted that Alternaria infection caused an increase in the serum level of (1–3)-β-D-glucan (BG) in the patients. To the best of our knowledge, no such finding has been reported in previously in the literature.



中文翻译:

皮肤交替病增强血清(1-3)-β-D-葡聚糖水平:一例病例并文献复习

被真菌Alternaria spp污染。通常被认为是由实验室来源引起的,偶尔会在免疫功能低下的患者中引起感染,称为细菌性真菌病。在这里,我们报道了一例由链格孢菌引起的皮肤链球菌病。该诊断基于对患者水泡病变的显微镜检查和真菌培养,并使用5种分子标记(即ITS,ATPase,Actin,rpb2和tef1)进行菌株鉴定。我们注意到,链格孢菌感染导致患者血清中(1-3)-β-D-葡聚糖(BG)含量增加。据我们所知,以前的文献中没有报道过这种发现。

更新日期:2020-12-28
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