Cellular senescence is a response with two faces in cancer: it restricts tumor proliferation, but it can also promote cancer progression and metastasis. In this issue of Cancer Cell, Guccini et al. uncover the role of TIMP1 in prostate cancer allowing a switch from tumor-controlling to tumor-promoting senescence.

中文翻译：

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癌症衰老的吉柯和海德：TIMP1控制从肿瘤控制到肿瘤促进衰老的转换

细胞衰老是癌症两方面的反应：它限制了肿瘤的扩散，但也可以促进癌症的进展和转移。在本期《癌细胞》中，Guccini等人。揭示了TIMP1在前列腺癌中的作用，从而允许从控制肿瘤的衰老转变为促进肿瘤的衰老。