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Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
European Journal of Clinical Microbiology & Infectious Diseases ( IF 3.7 ) Pub Date : 2020-12-23 , DOI: 10.1007/s10096-020-04116-y
V Hinić 1 , H M B Seth-Smith 1, 2 , S Damm 3 , P Amico 3 , N Khanna 4 , A Egli 1, 2 , V Bättig 4
Affiliation  

Mycoplasma hominis is a common colonizer of the lower genitourinary tract. Although its clinical relevance for causing urogenital infections in immunocompetent individuals is controversial, this bacterium has been involved in severe invasive infections in allograft recipients. In this report, we describe two cases of M. hominis infection in two young renal transplant recipients within the first month post-transplant. Although at first no epidemiological link between the two cases had been suspected, whole-genome sequencing (WGS) analysis showed that both isolates were identical, highly suggestive of an origin with the common organ donor.



中文翻译:

两名肾移植受者的意外人型支原体感染通过全基因组测序追溯到同一供体

人型支原体是下泌尿生殖道的常见定植菌。尽管其在免疫功能正常的个体中引起泌尿生殖道感染的临床相关性存在争议,但这种细菌已参与同种异体移植受者的严重侵袭性感染。在本报告中,我们描述了移植后第一个月内两名年轻肾移植受者中的两例人型分枝杆菌感染病例。尽管起初没有怀疑这两个病例之间存在流行病学联系,但全基因组测序 (WGS) 分析显示两个分离株是相同的,高度暗示其起源于共同的器官供体。

更新日期:2020-12-24
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