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Physical contact with cage mates modifies stress-induced hyperthermia in mice
Learning and Motivation ( IF 1.7 ) Pub Date : 2020-11-25 , DOI: 10.1016/j.lmot.2020.101692
Shigeru Watanabe

Using stress-induced hyperthermia (SIH) as an assay of stress levels, the effects of physical contact with conspecifics on restraint stress and the recovery from it were examined in mice. Restrained mice surrounded by freely moving cage mates showed enhanced SIH due to social inequality aversion. However, this stress enhancement was not observed when the subject was physically separated from cage mates by a transparent acrylic tube. Interestingly, social inequality in the dark room experimental paradigm enhanced SIH, which suggests that visual information does not play a crucial role in stress enhancement. Following release from restraint stress, the body temperatures of the mice gradually returned to baseline levels; this decrease was more rapid when the mice were placed in their home cage with cage mates. However, blocking physical contact using a transparent acrylic tube abolished the social facilitation of body temperature recovery. These results suggest that physical contact plays a crucial role in both stress emergence and recovery via social modification.



中文翻译:

与笼伴侣的物理接触改变了小鼠的应激诱导的体温过高

使用应激诱导的体温过高(SIH)作为应激水平的测定方法,在小鼠中检查了与特定物种的物理接触对约束应激的影响以及从约束应激中恢复的作用。由于社交不平等的厌恶,被自由活动的笼子伴侣包围的被束缚的小鼠表现出更高的SIH。但是,当对象通过透明的丙烯酸管与笼子伴侣物理隔离时,没有观察到这种压力增强。有趣的是,在暗室实验范式中的社会不平等增强了SIH,这表明视觉信息在压力增强中没有关键作用。从束缚压力中释放后,小鼠的体温逐渐恢复到基线水平。当将小鼠与笼伴侣一起放在自己的笼中时,这种下降更为迅速。然而,使用透明的丙烯酸管阻止身体接触,消除了体温恢复的社会便利性。这些结果表明,身体接触在压力产生和通过社交改变的恢复中起着至关重要的作用。

更新日期:2020-11-25
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