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Comparative analysis of spontaneous blinking and the corneal reflex
Royal Society Open Science ( IF 3.5 ) Pub Date : 2020-12-23 , DOI: 10.1098/rsos.201016
Julián Espinosa 1, 2 , Jorge Pérez 1, 2 , David Mas 1, 2
Affiliation  

Ocular surface health, the cognitive status, psychological health or human neurological disorders, among others, can be assessed by studying eye blinking, which can be differentiated in spontaneous, reflex and voluntary. Its diagnostic potential has provided a great number of works that evaluate their characteristics and variations depending on the subject's condition (sex, tiredness, health, …). The objective of this study was to analyse the differences in blinking kinematics of spontaneous and reflex blinks, distinguishing between direct and consensual reflexes, using a self-developed, non-invasive and image processing-based method. A video-oculography system is proposed using an air jet driven by a syringe to induce reflex and a high-speed camera to record the blinking of both eyes. The light intensity diffused by the eye changes during blinking and peaks when the eyelid closes. Sixty-second sequences were recorded of 25 subjects blinking. Intensity curves were off-line fitted to an exponentially modified Gaussian (EMG) function, whose σ, μ and τ parameters were analysed. A two-way analysis of variance (ANOVA) of these parameters was conducted to test the influence of the subject, the eye and blink type. In the closing phase, direct and consensual corneal reflexes are faster than spontaneous blinking, but there was no significant difference between them, nor between right and left eyes. In the opening phase, the direct corneal reflex was the slowest and significant differences appeared between right and left eyes.



中文翻译:

自发性眨眼与角膜反射的对比分析

可以通过研究眨眼来评估眼表健康,认知状态,心理健康或人类神经系统疾病,这些眨眼可分为自发性,反射性和自愿性。它的诊断潜力提供了大量的作品,这些作品可以根据受试者的状况(性,疲倦,健康等)评估其特征和变化。这项研究的目的是分析自发性眨眼和反射性眨眼在眨眼运动学方面的差异,使用自行开发的,非侵入性和基于图像处理的方法来区分直接反射和同意反射。提出了一种视频眼动系统,其使用由注射器驱动的喷气来引起反射并且使用高速相机来记录双眼的眨眼。眼睛散射的光强度在眨眼期间改变,而在眼睑闭合时达到峰值。记录了25位受试者眨眼的60秒序列。强度曲线离线拟合到指数修正的高斯(EMG)函数,其函数分析了σμτ参数。对这些参数进行了方差分析(ANOVA),以测试受试者,眼睛和眨眼类型的影响。在闭合阶段,直接和自愿的角膜反射比自发眨眼更快,但是它们之间以及左右眼之间没有显着差异。在开放阶段,直接角膜反射最慢,右眼和左眼之间出现显着差异。

更新日期:2020-12-23
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