This study aims to synthesis of 1-(2-hydroxy-4-methylphenyl)-3-phenylpropane-1,3-dione 3 in a quantitative yield from the reaction of ethyl benzoylacetate and m-cresol using a microwave in the absence of solvents. Phenylpropane-1,3-dione derivative 3 was used as the key synthetic intermediate for the synthesis of many derivatives in this study. A new pyrazole 12, pyrimidine 15, thiophene 37, 4H-pyrane 51 and pyridine derivatives 8, 28, 34, 41 and 46 were synthesized through different chemical reactions. The structures of the newly synthesized compounds were confirmed based on analytical and spectral data. The compounds were evaluated for both their in vitro antibacterial and antifungal activities. The compounds showed varying degree of antimicrobial activity.


中文翻译：

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某些新型吡唑，二氢吡啶硫酮，嘧啶，噻吩和4的合成及生物学研究

本研究旨在1-（2-羟基-4-甲基苯基）合成-3-苯基丙烷-1,3-二酮3从苯甲酰基乙酸乙酯和的反应以定量产率米在无溶剂的使用微波甲酚。在这项研究中，苯基丙烷-1,3-二酮衍生物3被用作合成许多衍生物的关键合成中间体。一种新的吡唑12 ，嘧啶15 ，噻吩37 ，4 ħ -pyrane 51和吡啶衍生物8 ，28 ，34 ，41和46通过不同的化学反应合成。根据分析和光谱数据确定了新合成化合物的结构。对化合物的体外抗菌和抗真菌活性进行了评估。该化合物显示出不同程度的抗微生物活性。