This study evaluated the prophylactic effect of Kadukkai maathirai in D-galactosamine (D-gal) induced hepatotoxicity in rats. D-galactosamine (D-gal) 400 mg/kg intraperitoneally was used to induce liver damage in rats. To assess the hepatoprotective effect of KM, three different doses of KM (36, 72 and 144 mg/kg body weight) were used. The hepatoprotective effect of KM was compared with standard drug silymarin (50 mg/kg). The biochemical parameters such as AST, ALT, ALP and total bilirubin were estimated. The livers were dissected out to look for histological changes. KM 144 mg/kg and silymarin showed a significant decrease in AST, ALP and total bilirubin. Both KM and silymarin significantly prevented decrease in liver weight. In KM treated groups, the liver did not show necrosis of hepatocytes, and apoptotic bodies with mild to moderate inflammatory infiltrate in the lobules and portal tracts. Hence, the results of this study confirms the hepatoprotective effect KM in rats.

中文翻译：

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Kadukkai maathirai（一种多草药传统的siddha制剂）可预防D-半乳糖胺诱发的大鼠肝坏死

这项研究评估了Kadukkai maathirai对D-半乳糖胺（D-gal）诱导的大鼠肝毒性的预防作用。腹膜内使用400 mg / kg的D-半乳糖胺（D-gal）诱导大鼠肝损伤。为了评估KM的肝保护作用，使用了三种不同剂量的KM（36、72和144 mg / kg体重）。将KM的肝保护作用与标准药物水飞蓟素（50 mg / kg）进行了比较。估算了诸如AST，ALT，ALP和总胆红素的生化参数。解剖肝脏以寻找组织学变化。KM 144 mg / kg和水飞蓟素显示AST，ALP和总胆红素显着降低。KM和水飞蓟素均可以显着阻止肝脏重量的减少。在KM治疗组中，肝脏未显示肝细胞坏死，以及轻度至中度炎性浸润的凋亡小体浸入小叶和门道。因此，该研究结果证实了KM对大鼠的肝保护作用。