Toxoplasmosis is a protozoal parasitic infection with serious consequences for immunocompromised people. The commercial pharmaceuticals used for treatment cause adverse effects and cannot provide a 100% cure. We investigated on antitoxoplasmal activities of eleven medicinal plants from seven different families used in the Al Qassim region of Saudi Arabia against infectious diseases. The plants were extracted in methanol. The methanolic extracts were evaluated against Toxoplasma gondii and the Vero cell line using the MTT assay. The results obtained revealed the maximum inhibitory effects of extracts of Citrullus colocynthis, Blepharis ciliaris and Aerva javanica with IC₅₀ values of 27.7, 65.2 and 78 µg/ml, respectively against the parasite. However, at the effective levels of antitoxoplasmal activity extracts, of all the above plant species showed different degrees of cytotoxicity against the Vero cell line with SI values of 1.3, 0.8 and 1.1. Hence, we suggest further studies to isolate the active ingredients are highly recommended.

中文翻译：

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评估从沙特阿拉伯加西姆采集的一些药用植物的体外抗弓形虫活性

弓形虫病是一种原生动物寄生虫感染，会对免疫功能低下的人造成严重后果。用于治疗的商业药物会引起不良影响，并且无法提供100％的治愈率。我们调查了沙特阿拉伯的Qassim地区使用的来自七个不同科的11种药用植物的抗弓形虫活性，以对抗传染病。将植物用甲醇萃取。使用MTT测定法评估了甲醇提取物对弓形虫和Vero细胞系的抵抗力。获得的结果表明，IC _50的西葫芦，Blepharis ciliaris和Aerva javanica提取物具有最大的抑制作用。寄生虫的抗药性值分别为27.7、65.2和78 µg / ml。然而，在抗弓形虫活性提取物的有效水平上，所有以上所有植物物种对Vero细胞系均显示出不同程度的细胞毒性，SI值为1.3、0.8和1.1。因此，我们强烈建议进一步研究以分离出有效成分。