Today, population growth, urbanization and industrialization have increased the contact of allliving things with heavy metals.With this study, we believe that the laboratory partial of the treatment with wet-cupping in migraine disease will be clarified. The aim of this study is to measure the levels of heavy metal and micro RNAs that are thought to play a act in migraine pathophysiology in female migraine patients and to reveal their differences compared to the control group.This study was carried out on a group of healthy women that were volunteer migraine patients who had applied to xxx university, Traditional / Complementary Medicine Center and on a control group. This study was conducted in 2018- Necmettin Erbakan University Konya Meram MedicalFaculty GETAT Center. This is a cross-sectional study. Group 1: control group women venous blood; Group 2: migraine women venous blood group; Group 3: women control group wet-cupping: Group 4: women with migraine group wet-cupping.In our study, Pb, Hg andNi wet-cupping blood rates were higher in venosus blood. The plasma miR-21 level of Group 2 was significantly higher than that of group 3 (p< 0.05). This result shows that giving venous blood is insufficient for heavy metals removal; wet-cupping is more effective. Prolong shield to Pb is happening at the same time with headaches. A closelylink between migraines and low Mg has been discovered. Low Mg, which might inhibit the production of nitricoxide, increases the distribution of substance P, so causing the narrow of cerebral vessels.

中文翻译：

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女性偏头痛患者同时抽取静脉和湿杯血液中的重金属和miRNA分析

如今，人口增长，城市化和工业化已经增加了生活必需品与重金属的接触。通过这项研究，我们相信将阐明偏头痛湿杯治疗的实验室部分。这项研究的目的是测量被认为在女性偏头痛患者偏头痛病理生理中起作用的重金属和微小RNA的水平，并揭示它们与对照组的差异。健康的女性，他们是偏头痛的自愿患者，已经向xxx大学，传统/补充医学中心和对照组申请。这项研究于2018年在Necmettin Erbakan University Konya Meram MedicalFaculty GETAT Center进行。这是一项横断面研究。第1组：对照组妇女静脉血；第2组：偏头痛妇女静脉血型；第3组：女性对照组湿杯法：第4组：偏头痛组女性湿杯法。在我们的研究中，静脉血中Pb，Hg和Ni湿杯法的血药率较高。第2组的血浆miR-21水平明显高于第3组（p＜0.05）。该结果表明，提供静脉血不足以去除重金属。湿拔罐更有效。头痛同时会延长对Pb的防护。人们发现偏头痛与低镁之间存在紧密联系。低镁可能会抑制一氧化氮的产生，会增加P物质的分布，从而导致脑血管狭窄。