Ferulago humulis Boiss. is an endemic species growing in Turkey. The aim of the study was to compare in vitro antioxidant and antimicrobial activities of the aerial parts (HFH) and rhizomes (RFH) of F. humulis. According to the results of antimicrobial and antioxidant activities of the extracts obtained from different parts of the plant, their phytochemical contents were evaluated. Petroleum ether (HFH-PE; RFH-PE), dichloromethane (HFH-DM; RFH-DM) and methanol (HFH-ME; RFH-ME) extracts from aerial parts (HFH) and rhizomes (RFH) of F. humulis were obtained for antimicrobial activity and examined by the agar hole diffusion and microdilution methods. Chromatographic and spectroscopic (¹H NMR, LS-MS and UV) techniques were used for the isolation of coumarin compounds from petroleum ether (RFH-PE) and dichloromethane (RFH-DM) extracts. Furthermore, antioxidant activity were assayed by the 4 different methods in methanol extracts (HFH-ME; RFH-ME). HFH-PE (MIC=6.25 mg/mL), RFH-PE (MIC=12.5 mg/mL) and RFH-DM (MIC=11 mg/mL) extracts against Staphylococcus aureus, and RFH-PE (MIC= 3.125 mg/mL), HFH-PE (MIC=6.25 mg/mL) extracts showed antimicrobial activity against S. epidermidis. HFH-PE (MIC=1.56 mg/mL), RFH-PE (MIC= 6.25 mg/mL) extracts exhibited antifungal activity against Candida tropicalis. From the rhizomes of F. humulis isoimperatorin, bergapten, oxypeucedanin, marmesin senecioate and oxypeucedanin hydrate known as furanocoumarins derivatives were isolated.

中文翻译：

---

ula草的生物学活性和植物化学含量。

Ferulago humulis Boiss。是在土耳其生长的特有物种。该研究的目的是比较在 体外抗氧化剂和地上部分（HFH）和根茎（RFH）的抗微生物活性F. humulis。根据从植物不同部位获得的提取物的抗微生物和抗氧化活性的结果，评估了它们的植物化学含量。从腐殖假丝酵母的地上部分（HFH）和根茎（RFH）中提取的石油醚（HFH-PE; RFH-PE），二氯甲烷（HFH-DM; RFH-DM）和甲醇（HFH-ME; RFH-ME）分别为获得的抗菌活性，并通过琼脂孔扩散和微量稀释方法进行检查。色谱和光谱学（¹使用1 H NMR，LS-MS和UV技术从石油醚（RFH-PE）和二氯甲烷（RFH-DM）提取物中分离出香豆素化合物。此外，通过4种不同方法在甲醇提取液（HFH-ME; RFH-ME）中测定了抗氧化活性。针对金黄色葡萄球菌的HFH-PE（MIC = 6.25 mg / mL），RFH-PE（MIC = 12.5 mg / mL）和RFH-DM（MIC = 11 mg / mL）提取物和RFH-PE（MIC = 3.125 mg / mL）mL），HFH-PE（MIC = 6.25 mg / mL）提取物表现出对表皮葡萄球菌的抗菌活性。HFH-PE（MIC = 1.56 mg / mL），RFH-PE（MIC = 6.25 mg / mL）提取物对热带假丝酵母具有抗真菌活性。从腐殖霉的根茎 分离出称为呋喃香豆素衍生物的异欧前胡素，香柠檬素，氧皮丹宁，千里香素马西汀和氧皮丹宁水合物。