The current study was designed for the delivery of mycophenolate mofetil using microsponges. Quasi-emulsification and double-emulsification techniques were used to develop ethyl cellulose (EC)- and xanthan gum-facilitated EC microsponges. The microsponges were characterized using micromeritics, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and surface morphology, particle size and zeta potential analyses; in vitro drug release and release kinetics were assessed by using various kinetic models. The studies revealed that the prepared microsponges offer free-flow properties with an adequate release profile and spherical porous surface morphology. The FTIR study did not reveal any interaction among the ingredients. XRD analysis confirmed the amorphous nature of mycophenolate mofetil. In vitro release studies showed that the sustained effect was maintained successfully up to 8 h. It can be concluded from the results that both EC and xanthan gum played an important role in the formulation of controlled-release microsponges of mycophenolate mofetil.

中文翻译：

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微海绵载体可安全有效地递送霉酚酸酯

当前的研究被设计为使用微海绵递送霉酚酸酯。准乳化和双乳化技术用于开发乙基纤维素（EC）和黄原胶促进的EC微海绵。使用微胶束，傅立叶变换红外光谱（FTIR），X射线衍射（XRD）以及表面形态，粒径和Zeta电位分析来表征微海绵。通过使用各种动力学模型评估体外药物释放和释放动力学。研究表明，制备的微海绵具有自由流动的特性，具有足够的释放特性和球形多孔表面形态。FTIR研究未揭示成分之间的任何相互作用。XRD分析证实了霉酚酸酯的无定形性质。体外释放研究表明，持续作用成功维持了长达8小时。从结果可以得出结论，EC和黄原胶在霉酚酸酯的控释微海绵制剂中均起着重要作用。