Background. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. Methods. The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. Results. The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: , 95% CI: -1.34, -0.42, ; 4 days: , 95% CI: -0.95, -0.54, ; 5 days: , 95% CI: -0.67, -0.25, ; 6-8 days: , 95% CI: -0.84, -0.26, ; 10-15 days: , 95% CI: -0.53, -0.20, ; 28-30 days: , 95% CI: -1.04, -0.02, ; ≥42 days: , 95% CI: -0.39, -0.06, ). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants. Conclusion. MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.

中文翻译：

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间充质干细胞治疗毒物致肾病的肾保护作用

背景。药物毒性引起的肾损伤在临床上越来越普遍。预防和治疗药物毒性引起的肾脏损害对于维持患者健康和减轻社会和经济负担至关重要。在这项研究中，我们进行了一项荟萃分析，以评估间充质干细胞 (MSCs) 在治疗毒物诱导的肾脏疾病中的肾脏保护作用。方法。检索了截至 2019 年 12 月 31 日的 Cochrane Library、Embase、ISI Web of Science 和 PubMed 数据库，以确定研究并提取数据，以评估 MSCs 使用 Cochrane Review Manager 5.3 版治疗毒物引起的肾脏疾病的疗效。共有 27 项研究符合条件并被选入本次荟萃分析。结果. 结果显示，MSC治疗组与对照组的血清肌酐水平在2、4、5、6-8、10-15、28-30和≥42天（2天：, 95% CI: -1.34, -0.42,; 4天：, 95% CI: -0.95, -0.54,; 5天：, 95% CI: -0.67, -0.25,; 6-8天：, 95% CI: -0.84, -0.26,; 10-15 天：, 95% CI: -0.53, -0.20,; 28-30 天：, 95% CI: -1.04, -0.02,; ≥42天：, 95% CI: -0.39, -0.06,）。此外，在 2-3、4-5、6-8 和≥28 天观察到 MSC 治疗组和对照组之间血尿素氮水平的差异。结果还表明，MSC 治疗减轻了毒物诱导的肾脏疾病中的炎症细胞、坏死小管、再生小管和肾间质纤维化。结论。间充质干细胞可能是毒物诱导的肾脏疾病的一种有前途的治疗剂。