How to Increase Further the Resolving Power of the Ultrahigh Magnetic Field FT ICR Instruments? The New Concept of the FT ICR Cell–the Open Dynamically Harmonized Cell as a Part of the Vacuum System Wall,Analytical Chemistry

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How to Increase Further the Resolving Power of the Ultrahigh Magnetic Field FT ICR Instruments? The New Concept of the FT ICR Cell–the Open Dynamically Harmonized Cell as a Part of the Vacuum System Wall
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-12-22 , DOI: 10.1021/acs.analchem.0c03237
Evgeny Nikolaev ₁ , Anton Lioznov ₁

Affiliation

FT ICR mass spectrometry continues to be the leader in the resolving power among all mass spectrometry methods. With the introduction of the dynamically harmonized FT ICR cell, it has become possible to achieve the resolving power of more than 10 million at m/q = 1000 with moderate magnetic fields of about 7 T. A further increase in the mass resolving power is desirable mainly for two reasons: with this we are increasing the number of resolved components in analyses of complex mixtures (like oil and natural organic matter (NOM)) and increasing the number of the mass of molecules for which a fine structure can be resolved. In recent years, some attempts have been made to further increase the mass resolving power by increasing the magnetic field and using the multielectrode detection method. An increase in the magnetic field to 21 T did not show a proportional increase in the mass resolving power. Likely, the reason for this is an insufficiently high vacuum to satisfy the requirement of an increase in the mean free path of ions with the increasing magnetic field power. We offer a new design for the FT ICR cell and the whole mass spectrometer, in which an open, dynamically harmonized FT ICR cell is integrated into a vacuum system with the outer surfaces of the cell electrodes at atmospheric pressure. In this design, the trap electrodes are the walls of the vacuum system and have the minimized active surfaces by combining the vacuum system surface and the cell surface into one. In this design, the pumping process is accelerated, and the factor of insufficient vacuum in FT ICR mass spectrometers with an ultrahigh magnetic field is eliminated.

中文翻译：

如何进一步提高超高磁场FT ICR仪器的分辨能力？FT ICR池的新概念-开放式动态协调池是真空系统壁的一部分

在所有质谱方法中，FT ICR质谱仪仍然是分辨力的领导者。通过引入动态协调的FT ICR单元，有可能在m / q时获得超过1000万的分辨能力= 1000，具有大约7 T的中等磁场。进一步需要提高质量分辨能力，主要有两个原因：为此，我们正在增加复杂混合物（例如油和天然有机物（NOM）的分析中可分辨组分的数量。）），并增加可以解决其精细结构的分子的数量。近年来，已经进行了一些尝试以通过增加磁场并使用多电极检测方法来进一步增加质量分辨能力。磁场增加到21 T并没有显示出质量分辨力的成比例增加。可能的原因是真空度不够高，无法满足随着磁场功率的增加而增加离子的平均自由程的要求。我们为FT ICR电池和整个质谱仪提供了一种新设计，其中一个开放的，动态协调的FT ICR电池被集成到一个真空系统中，并且电池电极的外表面处于大气压下。在这种设计中，捕获电极是真空系统的壁，并且通过将真空系统表面和电解池表面合并为一个，使捕获电极的活动表面最小化。在这种设计中，泵送过程得以加速，并且消除了具有超高磁场的FT ICR质谱仪中真空不足的因素。陷阱电极是真空系统的壁，通过将真空系统的表面和电解池的表面合而为一，从而使活性表面最小化。在这种设计中，泵送过程得以加速，并且消除了具有超高磁场的FT ICR质谱仪中真空不足的因素。陷阱电极是真空系统的壁，通过将真空系统的表面和电解池的表面合而为一，从而使活性表面最小化。在这种设计中，泵送过程得以加速，并且消除了具有超高磁场的FT ICR质谱仪中真空不足的因素。

更新日期：2021-01-26

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