Ferroptosis is a newly discovered form of necrotic cell death characterized by its dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinson’s disease (PD), a major neurodegenerative disease, has been indicated using animal models. Although PD is associated with both genetic and environmental factors, sporadic forms of PD account for more than 90% of total PD. Following the importance of environmental factors, various neurotoxins are used as chemical inducers of PD both in vivo and in vitro. In contrast to other neurodegenerative diseases such as Alzheimer’s and Huntington’s diseases (AD and HD), many of the characteristics of PD can be reproduced in vivo by the use of specific neurotoxins. Given the indication of ferroptosis in PD pathology, several studies have been conducted to examine whether ferroptosis plays role in the loss of dopaminergic neurons in PD. However, there are still few reports showing an authentic form of ferroptosis in neuronal cells during exposure to the neurotoxins used as PD inducers. In this review article, we summarize the history of the uses of chemicals to create PD models in vivo and in vitro. Besides, we also survey recent reports examining the possible involvement of ferroptosis in chemical models of PD.

Ferroptosis是一种新发现的坏死性细胞死亡形式，其特征在于它依赖于铁和脂质过氧化作用。自从使用动物模型已经表明了肥大症涉及帕金森氏病（PD）（一种主要的神经退行性疾病）以来，肥大症在神经变性领域引起了广泛的关注。尽管局部放电与遗传和环境因素均相关，但散发的局部放电占总局部放电的90％以上。继环境因素的重要性之后，各种神经毒素被用作PD的化学诱导剂。体内 和 体外。与其他神经退行性疾病（如阿尔茨海默氏病和亨廷顿氏病）（AD和HD）相反，PD的许多特征均可重现体内通过使用特定的神经毒素。给定PD病理中有肥大症的征兆，已经进行了一些研究来检查肥大症是否在PD中多巴胺能神经元的丧失中起作用。但是，仍然很少有报道显示在暴露于用作PD诱导剂的神经毒素期间，神经元细胞中铁氧体肥大症的真实形式。在这篇评论文章中，我们总结了使用化学药品创建局放模型的历史体内 和 体外。此外，我们还调查了最近的报告，研究了肥大症在PD化学模型中的可能参与。